Your Partner in Drug Discovery
We are leveraging breakthrough technologies to transform drug discovery.
Epitope mapping:
The process of identifying the regions that a therapeutic binds to its target antigen.
Acquiring detailed knowledge of epitope interactions is critical in the lead validation stage of drug discovery, as it provides insight into the binding mechanism, enabling the optimization of various properties of a drug candidate such as specificity and binding affinity.
Furthermore, a detailed epitope map can provide stronger intellectual property (IP) protection. Epitope claims included in drug patents protect against binders to a specific epitope of the given target, allowing for much broader IP protection.
The Future of Epitope Mapping.
PLIMB is a revolutionary technique that provides high resolution data on the native, in-solution structure of the therapeutic and target antigen in a rapid analysis that is applicable to a wide range of proteins.
Other Services
Protein Small Molecule Interaction
- Gain detailed insights into - ligand-protein interactions.
- Pinpoint amino acid level hotspots to locate binding interactions.
- Generate a detailed map of ligand-induced higher-order structural changes.
Protein-Protein Interaction
- Map the specific regions of interactions between proteins.
- Characterize drug/receptor interactions, protein aggregation, or dimerization.
Protein Higher Order Structure
- Characterize and detect subtle differences in protein higher order structure (HOS).
- Use HOS for measuring comparability studies for characterizing biosimilar-innovator differences, expression platforms, formulation, or changes based on buffer or environmental conditions.
Case Studies
