Structure to Enable Discovery

Immuto Scientific is on a mission to demystify and democratize protein structure, function, and dynamics - revolutionizing drug discovery and therapeutic development. Via our proprietary platform, we generate detailed, native-state structures at amino acid-level resolution for any protein or peptide, alone or in a complex, in just a few weeks.

Our Services:
Epitope MappingProtein Small Molecule InteractionProtein-Protein InteractionProtein-Protein InteractionMembrane Protein CharacterizationHRF for Aggregation
Get in Touch.


Your therapeutics save lives. We save you time and resources.

Let's Talk
Quick Turnaround
‍Results in 2 weeks to perform rapid lead optimization iteration
‍
‍Cost Reduction
‍Mulitplexed analysis on many lead candidates simultaneously
‍
‍Native Analysis
‍In solution structural analysis for biologically-relevant results
‍
Faster IP Filings
‍Detailed epitope data for stronger patent claims
‍
Compatibility
‍Can be used to analyze challenging membrane protein targets such GPCRs

A New Paradigm in Drug Discovery.

Protein structural analysis is an essential step in the drug discovery process, and compared to all other methods used today, our suite of proprietary technologies enables developers to investigate interactions of therapeutics and their targets with an unprecedented degree of accuracy and speed.
‍
That means significantly reducing uncertainty —  and the costs related to it.

Novel Epitope Mapping:

Unlike other methods, our groundbreaking suite of  technologies for the first time makes it possible to map epitopes and paratopes quickly, reliably through a native, in-solution analysis.

Protein Small Molecule Interaction:
  • Gain detailed insights into ligand-protein interactions.
  • Pinpoint amino acid level hotspots to locate binding interactions.
  • Generate a detailed map of ligand-induced higher-order structural changes.
Protein-Protein Interaction:
  • Protein-Protein Interaction:
  • Characterize drug/receptor interactions, protein aggregation, or dimerization.
Protein Higher Order Structure:
  • Characterize and detect subtle differences in protein higher order structure (HOS).
  • Use HOS for measuring comparability studies for characterizing biosimilar-innovator differences, expression platforms, formulation, or changes based on buffer or environmental conditions.

Lead Optimization.
Optimized.

We partner with pharmaceutical companies in drug discovery to streamline their lead optimization, helping to reduce cycle times, increase lead candidates, and maximize the probability of drug success leading up to clinical trials.

Quick Turnaround:

Get results  in 2–3 weeks to perform rapid lead optimization iteration

Reduce Cost:

Can be performed on many lead candidates simultaneously

Native Analysis:

Native structure and protein conditions for biologically-relevant results

Faster IP Filings:

Better epitope findings earlier make for stronger claims

Protein Compatibility:

Can be used to analyze challenging protein targets

Introducing PLIMB:

Rapid High-Resolution Analysis

Our core proprietary technology, PLIMB (Plasma Induced Modification of Biomolecules) is setting a new standard for epitope mapping and structural analysis.

PLIMB provides high-resolution data on antibody binding while eliminating other costly inefficiencies, so developers can zero-in on multiple high-probability leads at the same time.

Our core proprietary technology, PLIMB (Plasma Induced Modification of Biomolecules) is setting a new standard for epitope mapping and structural analysis.
‍
PLIMB provides high-resolution data on antibody binding while eliminating other costly inefficiencies, so developers can zero-in on multiple high-probability leads at the same time.

No lengthy protein crystallization required
Performed in biologically-relevant buffer
Requires minimal sample sizes (>5ug per sample)
High throughputs for multiple, synchronous targeting
Analyzes proteins incompatible with other techniques
Prevents denaturization through sub-microsecond timescale

The Proof Is in the Papers.

Our findings have been published in some of the most prestigious peer-reviewed journals. Your therapeutics save lives. We save you time and resources.

Plasma-Generated OH Radical Production for Analyzing 3D Structure

Effect of Frequency and Applied Voltage of An Atmospheric-Pressure

In Good Company

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Structure to enable discovery.

We are on a mission to demystify and democratize protein structure, function, and dynamics - revolutionizing drug discovery and therapeutic development. Via our proprietary platform, we generate detailed, native-state structures at amino acid-level resolution for any protein or peptide, alone or in a complex, in just a few weeks.
‍
Our Services
‍
Epitope/Paratope MappingProtein-Small Molecule InteractionProtein-Protein InteractionHigher Order StructuresMembrane Protein CharacterizationAntibody Aggregation Analysis

Don't be in the dark about your target's structure, function, and dynamics -
get in touch and advance your candidates.

Let's Talk
Quick Turnaround
‍
Results in 2 weeks to perform rapid lead optimization iteration
‍

‍Cost Reduction
‍
Mulitplexed analysis on many lead candidates simultaneously
‍

‍Native Analysis
‍
In solution structural analysis for biologically-relevant results
‍
‍
Faster IP Filings
‍
Detailed epitope data for stronger patent claims
‍

Compatibility
‍
Can be used to analyze challenging membrane protein targets such GPCRs
‍

Quick Turnaround

Results in 2 weeks to perform rapid lead optimization iteration

‍Cost Reduction

‍Mulitplexed analysis on many lead candidates simultaneously

‍Native Analysis

‍In solution structural analysis for biologically-relevant results

‍Faster IP Filings

Detailed epitope data for stronger patent claims

Compatibility

Can be used to analyze challenging membrane protein targets such GPCRs
The Solution

A New Paradigm in Drug Discovery.
‍

Protein structural analysis is an essential step in the drug discovery process, and compared to all other methods used today, our suite of proprietary technologies enables developers to investigate interactions of therapeutics and their targets with an unprecedented degree of accuracy and speed.
‍
That means significantly reducing uncertainty —  
and the costs related to it.

Novel Epitope Mapping:

Unlike other methods, our groundbreaking suite of  technologies for the first time makes it possible to map epitopes and paratopes quickly, reliably through a native, in-solution analysis.

Protein Small Molecule Interaction:
  • Gain detailed insights into ligand-protein interactions.
  • Pinpoint amino acid level hotspots to locate binding interactions.
  • Generate a detailed map of ligand-induced higher-order structural changes.
Protein-Protein Interaction:
  • Map the specific regions of interactions between proteins.
  • Characterize drug/receptor interactions, protein aggregation, or dimerization.
Protein Higher Order Structure:
  • Characterize and detect subtle differences in protein higher order structure (HOS).
  • Use HOS for measuring comparability studies for characterizing biosimilar-innovator differences, expression platforms, formulation, or changes based on buffer or environmental conditions.


Lead Optimization.
Optimized.
‍

We partner with pharmaceutical companies in drug discovery to streamline their lead optimization, helping to reduce cycle times, increase lead candidates, and maximize the probability of drug success leading up to clinical trials.

No lengthy protein crystallization required
Performed in biologically-relevant buffer
Requires minimal sample sizes (>5ug per sample)
High throughputs for multiple, synchronous targeting
Analyzes proteins incompatible with other techniques
Prevents denaturization through sub-microsecond timescale


Rapid High-Resolution Analysis: Meet PLIMB

Our core proprietary technology, PLIMB (Plasma Induced Modification of Biomolecules) is setting a new standard for epitope mapping and structural analysis.
‍
PLIMB provides high-resolution data on antibody binding while eliminating other costly inefficiencies, so developers can zero-in on multiple high-probability leads at the same time.

The World Needs Pharma. Pharma Needs Us.

Our team is made up of leading scientists and researchers boasting a collective 20+ years of experience in protein biochemistry, mass spectrometry, and drug discovery and development. Our state-of-the-art technologies and expertise are changing drug discovery as we know it.

Therapeutic Areas / Disease Understanding
Candidate Selection
Discovery / Screening Efforts
Process / Analytical Methods Development
Introducing PLIMB:

Rapid High-Resolution Analysis

Our core proprietary technology, PLIMB (Plasma Induced Modification of Biomolecules) is setting a new standard for epitope mapping and structural analysis.
‍
PLIMB provides high-resolution data on antibody binding while eliminating other costly inefficiencies, so developers can zero-in on multiple high-probability leads at the same time.

No lengthy protein crystallization required
Performed in biologically-relevant buffer
Requires minimal sample sizes (>5ug per sample)
High throughputs for multiple, synchronous targeting
Analyzes proteins incompatible with other techniques
Prevents denaturization through sub-microsecond timescale

The World Needs Pharma. Pharma Needs Us.

Our team is made up of leading scientists and researchers boasting a collective 20+ years of experience in protein biochemistry, mass spectrometry, and drug discovery and development. Our state-of-the-art technologies and expertise are changing drug discovery as we know it.

Therapeutic Areas / Disease Understanding
Candidate Selection
Discovery / Screening Efforts
Process / Analytical Methods Development
Introducing PLIMB:

Rapid High-Resolution Analysis

Our core proprietary technology, PLIMB (Plasma Induced Modification of Biomolecules) is setting a new standard for epitope mapping and structural analysis.
‍
PLIMB provides high-resolution data on antibody binding while eliminating other costly inefficiencies, so developers can zero-in on multiple high-probability leads at the same time.

No lengthy protein crystallization required
Performed in biologically-relevant buffer
Requires minimal sample sizes (>5ug per sample)
High throughputs for multiple, synchronous targeting
Analyzes proteins incompatible with other techniques
Prevents denaturization through sub-microsecond timescale

The World Needs Pharma. Pharma Needs Us.

Our team is made up of leading scientists and researchers boasting a collective 20+ years of experience in protein biochemistry, mass spectrometry, and drug discovery and development. Our state-of-the-art technologies and expertise are changing drug discovery as we know it.

Therapeutic Areas / Disease Understanding
Candidate Selection
Discovery / Screening Efforts
Process / Analytical Methods Development

The Proof Is in the Papers.

Our findings have been published in some of the most prestigious peer-reviewed journals. Your therapeutics save lives. We save you time and resources.

Plasma-Generated OH Radical Production for Analyzing 3D Structure in Protein Therapeutics

Effect of Frequency and Applied Voltage of An Atmospheric-Pressure Dielectric-Barrier Discharge on Breakdown and Hydroxyl-Radical Generation with a Liquid Electrode

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In Good Company.

We’ve attracted the attention of industry leaders, investors, and clients, including the top pharmaceutical companies and biotechnology firms in the US, and these esteemed institutional partners.

University of Wisconsin Madison

Wisconsin Alumni Research Foundation

National Science Foundation

Wisconsin Investment Partners

Milwaukee Venture Partners

National Institute of Health

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All rights reserved.